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The papers, and their limits.

Each record states what was studied, in whom, at what dose and for how long, and how that dose compares to one serving of LOCK IN.

How we cite

  1. 01

    We read the paper

    Every record here was checked against the primary source. Two of the three came to us from the manufacturer with incorrect figures — one understated a dose by a factor of four, the other understated a result. Both are corrected, and the corrections are printed below the records rather than quietly fixed.

  2. 02

    We publish the dose gap

    Where a study used more of an ingredient than one serving contains — and in two of three cases it used far more — the difference sits next to the finding, in the same size type.

  3. 03

    We name the material, not just the ingredient

    A trial on dried mushroom powder is not a trial on an extract. A trial on a specific fermented product is not a trial on the genus. Where the material differs from what is in this bottle, we say so.

  4. 04

    Research is not a result

    None of this is evidence about what this product will do for you. It is the context in which these ingredients were chosen, and nothing more than that.

The record

  1. R—01

    Lion’s Mane

    Verified against source

    Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial

    Design
    Randomised, double-blind, parallel-group, placebo-controlled
    Population
    30 Japanese adults aged 50–80 with mild cognitive impairment, randomised 15 / 15
    Dose studied
    3,000 mg/day — four 250 mg tablets of 96% dried Hericium erinaceus powder, three times daily
    Duration
    16 weeks

    What it found

    The Yamabushitake group scored significantly higher on the Revised Hasegawa Dementia Scale than placebo at weeks 8, 12 and 16.

    Vitelyn uses 100 mg of mushroom extract per serving

    Two differences, and both matter. The trial used 3,000 mg a day — thirty times the amount here — and it used dried whole mushroom powder, where this formula uses an extract. Powder and extract are not comparable milligram for milligram, so the real distance is unknown rather than merely large. The participants also had diagnosed mild cognitive impairment, which is not who this product is for.

    Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Phytotherapy Research. 2009;23(3):367–372.

    DOI 10.1002/ptr.2634PMID 18844328 Read the source ↗

  2. R—02

    Cordyceps

    Verified against source

    Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial

    Design
    Randomised, double-blind, placebo-controlled pilot
    Population
    20 healthy adults aged 50–75
    Dose studied
    1,000 mg/day — 333 mg of Cs-4 three times daily
    Duration
    12 weeks

    What it found

    Metabolic threshold rose 10.5% in the Cs-4 group (p < 0.02) and ventilatory threshold 8.5%, with no significant change in the placebo group. VO₂max did not change in either group.

    Vitelyn uses 100 mg of mushroom extract per serving

    Ten times the amount here, and a different material: Cs-4 is a specific fermented mycelial product, not the mushroom extract on this label. The changes were also measured within the treatment group before and after rather than against placebo directly, which is a weaker form of evidence than a between-group difference.

    Correction

    We were told this trial found no statistically significant effect. It did report significance on metabolic threshold (p < 0.02). Understating a result is still getting it wrong, so this has been corrected too.

    Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Journal of Alternative and Complementary Medicine. 2010;16(5):585–590.

    DOI 10.1089/acm.2009.0226 Read the source ↗

  3. R—03

    Vitamin B12

    Verified against source

    Biomarkers of cobalamin (vitamin B12) deficiency and its application

    Design
    Clinical review
    Population
    General and older adult populations
    Dose studied
    Reviews the markers used to establish status, against a 2.4 mcg daily reference intake
    Duration
    —

    What it found

    Sets out the markers used to identify cobalamin deficiency — mean corpuscular volume, serum cobalamin, holotranscobalamin, methylmalonic acid and homocysteine — and how each should be interpreted.

    Vitelyn uses 500 mcg per serving

    500 mcg sits well above the 2.4 mcg reference intake, deliberately: above a few micrograms, oral B12 is absorbed by passive diffusion, which is inefficient. This is evidence that B12 status matters and can be measured. It is not evidence that more B12 does anything for you if your status is already adequate.

    Chatthanawaree W. The Journal of Nutrition, Health & Aging. 2011;15(3):227–231.

    DOI 10.1007/s12603-010-0280-xPMID 21369672 Read the source ↗

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Nothing on this page is a claim about what this product will do. If you believe a record here is inaccurate, write to hello@vitelyn.com and we will correct it.

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